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Physiologic sestamibi uptake in lactating breast

Imaging findings

Sestamibi SPECT/CT demonstrates intense, diffuse physiologic uptake in both breasts, along with a parathyroid adenoma in the superior mediastinum/thymic bed.

Key takeaways

Lactation causes intense physiologic accumulation of Tc-99m sestamibi in the breasts, which should not be confused with malignancy. It is a helpful sign for identifying active lactation.

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