CTICasesTransfusion-Related Lymph Node Hemosiderosis in Sickle Cell Disease
Imaging findings
Chest CT in a patient with sickle cell disease reveals dense, hyperattenuating lymph nodes within the mediastinum and porta hepatis on a non-contrast scan, caused by severe iron deposition from chronic blood transfusions.
Key takeaways
Like hepatic or splenic hemosiderosis, chronic transfusion therapy in sickle cell disease can result in marked iron accumulation within regional lymph nodes, leading to diagnostic hyperattenuation on non-contrast CT that mimics calcified granulomatous disease.
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