CTICasesLepidic Adenocarcinoma
Imaging findings
Serial chest CT scans over a 17-month period show a pure ground-glass nodule in the lung parenchyma that progressively increases in size and develops small, irregular internal solid components.
Key takeaways
The development of new solid components within a pre-existing ground-glass nodule (GGO) is a highly specific sign of progression from atypical adenomatous hyperplasia or adenocarcinoma in situ to invasive adenocarcinoma. Thin-section CT is critical to identify these subtle solid foci, which correspond histologically to areas of stromal invasion, often requiring surgical resection.
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