CTICasesAdenocarcinoma Mimicking Focal Fibrosis in IPF Patient
Imaging findings
In a patient with known UIP/IPF, CT initially showed a new band of consolidation in the left upper lobe, which grew over time, then stabilized for several months, and even showed slight regression, appearing like focal fibrosis. However, post-transplant pathology revealed a 3.7 cm adenocarcinoma within this area.
Key takeaways
Lung cancer can arise in patients with IPF, and its imaging appearance can be deceptive, sometimes mimicking focal fibrosis or showing a period of stability or even slight regression, confounding diagnosis. Given the increased incidence of lung cancer in IPF patients, vigilance and further workup (e.g., biopsy) are crucial, even for lesions that don't follow typical growth patterns.
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