CTICasesGestational Trophoblastic Neoplasia (Pulmonary Metastases)
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Imaging findings
Chest radiograph reveals multiple well-defined pulmonary nodules. CT confirms the presence of these very well-circumscribed, low-attenuation nodules, which show peripheral enhancement, consistent with hematogenous spread of neoplasm. Abdominal images demonstrate the primary molar pregnancy within the uterus, characterized by abnormal tissue (non-viable fetus). Post-treatment imaging shows dramatic regression of the pulmonary nodules.
Key takeaways
Gestational trophoblastic neoplasia (GTN), including complications of molar pregnancy, can lead to pulmonary metastases. These often appear as well-defined, low-attenuation nodules with peripheral enhancement, reflecting their hypervascular nature. A hallmark of GTN is its remarkable sensitivity to chemotherapy, particularly methotrexate, leading to dramatic regression of metastatic lesions. This case highlights the importance of whole-body staging in molar pregnancy.
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