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Solitary Histoplasmosis Granuloma

Imaging findings

Chest radiographs and CT demonstrate a large, benign-appearing calcified nodule in the posterior right lower lobe. The nodule shows classic targetoid/laminated calcification, representing an old histoplasmosis granuloma.

Key takeaways

Solitary calcified granulomas from Histoplasma capsulatum often demonstrate laminated, targetoid, or central calcification. They can easily be missed on frontal radiographs if they lie in blind spots such as the posterior costophrenic sulci.

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