CTICasesPrimary Mucinous Adenocarcinoma of the Lung with False-Negative Biopsy
Imaging findings
Serial radiographs and CT scans spanning several years show a slow-growing focal consolidation in the anterior basal segment of the right lower lobe, accompanied by minor satellite nodules. A CT-guided core biopsy performed early in the course yielded only benign cells. Despite the negative biopsy, the lesion continued to slowly enlarge over several years, and surgical resection eventually confirmed mucinous adenocarcinoma.
Key takeaways
Mucinous adenocarcinoma can present as a slow-growing, indolent focal consolidation mimicking chronic or organizing pneumonia. Radiologists must remain highly suspicious of persistent or enlarging consolidative lesions; a single "benign" percutaneous biopsy should not rule out malignancy when the imaging findings and temporal growth remain highly suspicious.
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