CTICasesRosai-Dorfman Disease
Imaging findings
CT chest shows massive mediastinal, hilar, and retroperitoneal lymphadenopathy, accompanied by diffuse perilymphatic micronodules along the bronchovascular bundles. Follow-up CT after corticosteroid therapy shows marked regression of both nodes and nodules.
Key takeaways
Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare, non-Langerhans cell histiocytosis. While classically presenting in young adults with massive cervical adenopathy, it can occur in older adults and involve the chest, mimicking sarcoidosis both radiographically and pathologically.
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