CTICasesAntisynthetase Syndrome with Organizing Pneumonia and Interstitial Lung Disease
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Imaging findings
Original radiograph (2011) shows low lung volumes and patchy peripheral/peribronchial consolidation in the bases. CT (2011) shows peripheral ground-glass consolidation in non-segmental and perilobular distributions, with some subpleural sparing, consistent with organizing pneumonia and possible NSIP. Follow-up CT (2 years later) shows marked diminution of consolidation, with residual perilobular reticulation indicating mild fibrosis. Patient tested positive for anti-Jo1 antibody.
Key takeaways
Antisynthetase syndrome, often associated with anti-Jo1 antibodies, frequently presents with interstitial lung disease, typically organizing pneumonia or NSIP, which can respond to immunosuppression. Anti-Jo1 antibodies are highly correlated with pulmonary fibrosis in these patients. Imaging shows peripheral/peribronchial consolidation and can progress to fibrosis.
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