CTICasesBurned Out Extramedullary Hematopoiesis with Fatty Replacement in Beta Thalassemia
▶ Watch on YouTube — age-restricted, cannot embed here
Imaging findings
Chest radiograph shows lobulated soft tissue abnormalities behind the heart. Earlier CT (from a few months prior) shows these as fatty masses. Even older CT (from years prior) shows much larger soft tissue attenuation masses of extramedullary hematopoiesis along the spine, with dilated bones. Following radiation and transfusion therapy, these masses have significantly regressed and undergone fatty replacement.
Key takeaways
Extramedullary hematopoiesis, commonly seen in conditions like beta thalassemia, can regress and undergo fatty replacement following treatment with radiation therapy and regular transfusions. This demonstrates the reduction of the stimulus for hematopoiesis. The resulting fatty masses can be a differential for posterior mediastinal masses.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Neurofibromatosis with Ruptured Intercostal Artery AneurysmsCongenital
- Massive Ascending Aortic Aneurysm due to Healed Non-specific VasculitisVascular
- Ruptured Sinus of Valsalva Aneurysm with Anomalous Septal Course of Left Main Coronary ArteryCongenital
- Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) with Carcinoid TumorsNeoplastic
- Perimembranous Ventricular Septal Defect as a Transcatheter Aortic Valve Implantation (TAVI) ComplicationIatrogenic
- Primary Cardiac Diffuse Large B-cell Lymphoma of the Left VentricleNeoplastic
- Luxatio Erecta (Inferior Glenohumeral Dislocation)Trauma
- Benign Solitary Fibrous Tumor of the PleuraNeoplastic
See all cases from September 20, 2014 →