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Disseminated Nocardia Nova Infection

Imaging findings

CT chest in an immunocompromised patient shows a solitary, thick-walled cavitary nodule in the right upper lobe with a ground-glass halo. Brain MRI shows multiple ring-enhancing lesions, confirmed as disseminated Nocardia nova.

Key takeaways

Nocardia is an opportunistic, filamentous bacterium that typically infects immunocompromised hosts. In the lungs, it frequently presents as upper-lobe-predominant cavitary nodules or masses that mimic tuberculosis or invasive aspergillosis. Dissemination to the central nervous system is common and presents as multiple brain abscesses.

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