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Dendriform Pulmonary Ossification

Imaging findings

Chest radiograph and high-resolution CT show high-attenuation, branching, spicular, calcified nodules located predominantly in the subpleural and lower-lobe regions, associated with a background pattern of chronic fibrosing interstitial lung disease.

Key takeaways

Dendriform pulmonary ossification is a rare form of metaplastic bone formation within the lung parenchyma, characterized by branching spicules of mature bone tracking along the interstitium. While DPO can be an incidental finding in slowly progressive fibrosis, it is also frequently found pathologically in patients with severe, rapidly progressive fibrosing interstitial lung disease such as usual interstitial pneumonia.

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