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Coccidioidomycosis presenting with multiple nodules showing the halo sign

Imaging findings

CT scan of an older female 'snowbird' returning from Phoenix shows multiple pulmonary nodules with surrounding ground-glass halos (halo sign) and a dominant right lower lobe mass-like consolidation.

Key takeaways

While the halo sign is classically associated with angioinvasive aspergillosis, it can also be seen in acute coccidioidomycosis. Travel history to endemic regions (such as Arizona) is a critical diagnostic clue.

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