CTICasesSmoking-related airspace enlargement with fibrosis
Imaging findings
Chest CT shows large, irregular subpleural air spaces in the upper lobes and posterior lower lobes, without significant traction bronchiectasis or typical basal-predominant honeycombing. Surgical biopsy confirmed airspace enlargement with fibrosis.
Key takeaways
Airspace enlargement with fibrosis (AEF) is a distinct histopathological entity commonly found in smokers, characterized by large, irregular cystic air spaces mimicking honeycombing. Differentiating AEF from idiopathic pulmonary fibrosis (UIP) is crucial for prognosis.
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