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Laryngeal papillomatosis with malignant transformation

Imaging findings

Chest CT shows nodular thickening along the trachea and a large, irregular consolidative mass with surrounding ground-glass opacity in the right upper lobe in a patient with a history of recurrent respiratory papillomatosis. Histopathology confirmed squamous cell carcinoma.

Key takeaways

Tracheobronchial papillomatosis is a rare manifestation of human papillomavirus (HPV) infection. Although benign, it can rarely undergo malignant transformation to squamous cell carcinoma, presenting as progressive parenchymal masses.

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