CTICasesGM-CSF-Induced Diffuse Skeletal FDG Uptake
Imaging findings
PET/CT imaging in a patient with a history of diffuse large B-cell lymphoma demonstrates intense, diffuse, and relatively homogeneous skeletal FDG uptake throughout the bone marrow. There is a lack of focal hypermetabolic lesions elsewhere in the body to suggest active lymphoma.
Key takeaways
Therapy with bone marrow stimulants such as granulocyte-macrophage colony-stimulating factor (GM-CSF) causes marked, diffuse hematopoietic marrow activation, leading to intense and widespread skeletal FDG uptake on PET/CT. This physiological and metabolic drug effect mimics diffuse lymphomatous marrow infiltration or bone metastases but is typically more homogeneous and uniform across the skeleton.
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