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Diffuse Primary Pulmonary Adenocarcinoma Mimicking Systemic Disease

Imaging findings

Chest CT in an elderly patient demonstrates diffuse, widespread areas of consolidation and ground-glass opacity throughout both lungs. The pattern is highly extensive and mimics a systemic inflammatory or infectious process, but pathology confirms diffuse primary pulmonary adenocarcinoma of the lung.

Key takeaways

Diffuse pulmonary adenocarcinoma can present with extensive, multifocal consolidative and ground-glass opacities that closely mimic lobar pneumonia, pulmonary edema, or diffuse alveolar hemorrhage. Tissue biopsy is necessary to differentiate this neoplastic process from benign systemic diseases.

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