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Eosinophilic granulomatosis with polyangiitis with severe lymphadenopathy

Imaging findings

Chest CT in a 15-year-old boy shows peripheral, basal-predominant interstitial thickening, septal lines, pleural fluid, and massive mediastinal, subcarinal, axillary, and supraclavicular lymphadenopathy. Biopsies of the nodes demonstrated reactive lymphadenopathy.

Key takeaways

Although lymphadenopathy is a known feature of eosinophilic granulomatosis with polyangiitis, massive mediastinal, hilar, and axillary lymphadenopathy of this magnitude is extremely rare. It can mimic a lymphoma or lymphoproliferative disorder, and it resolves following anti-inflammatory therapy.

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