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Metastatic breast cancer presenting as malignant pleural effusion

Imaging findings

Chest CT, sagittal, and coronal reconstructions demonstrate a large pleural effusion and nodular pleural thickening along the anterior and basal pleural surfaces and cardiaphrenic fat space, associated with an FDG-avid primary breast mass on PET-CT.

Key takeaways

Pleural metastases from breast cancer can present as a unilateral pleural effusion with subtle pleural nodularity or thickening, particularly along the anterior and basal pleura, resembling mesothelioma. Cardiaphrenic lymphadenopathy or subtle fissural nodularity can also be clues to a malignant etiology.

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