CTICasesUndifferentiated Aggressive Neoplasm
▶ Watch on YouTube — age-restricted, cannot embed here
Imaging findings
A large, heterogeneous mediastinal mass with peripheral nodular enhancement, internal necrosis, and intralesional air lucencies post-biopsy. Imaging also showed significant vascularity, connection to the pericardium, and an associated pericardial effusion. Pathological examination revealed pleomorphic cellular proliferation of enlarged hyperchromic cells with irregular nuclear contrast, multinucleated/multilobulated cells, collagenous stroma, and mitotic figures, with focal necrosis. Extensive immunohistochemical staining for various neoplasms (including vascular, smooth muscle, hematopoietic, melanoma, carcinoma, lymphoma, and others) was negative, leading to a diagnosis of undifferentiated aggressive neoplasm.
Key takeaways
Aggressive, undifferentiated mediastinal neoplasms in young patients, particularly in the midline, can be diagnostically challenging due to their pleomorphic nature and resistance to classification by extensive immunohistochemical panels. Nut midline carcinoma should be considered in such cases.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Pulmonary AmyloidosisMetabolic
- Hard Metal Pneumoconiosis from Tungsten CarbideExposure
- MALT Lymphoma of the LungNeoplastic
- Crack Cocaine LungExposure
- Extramedullary Leukemia (Myeloid Sarcoma/Chloroma) with Thymic and Paraspinal InfiltrationNeoplastic
- Hodgkin's LymphomaNeoplastic
- Pneumothorax with Adhesions (in Cystic Fibrosis)Other
- Intercostal Artery Pseudoaneurysm secondary to Severe ScoliosisVascular
See all cases from April 17, 2015 →
Related Neoplastic cases
- Sterilized Mixed Germ Cell Tumor with Teratomatous Elements
- Mucinous Adenocarcinoma with Lymphatic Carcinomatosis
- Papillary Fibroelastoma
- Undifferentiated Pleural Sarcoma with Rib Destruction
- Primary Cardiac Intimal Sarcoma
- Medullary Thyroid Carcinoma with Bronchial Artery Aneurysms and Cystic Lung Disease (Amyloidosis-related)