CTICasesPulmonary Graft-Versus-Host Disease
Imaging findings
Serial chest CT scans show diffuse, patchy, bilateral, multi-lobar ground-glass opacities and areas of consolidation. Follow-up imaging obtained after the initiation of high-dose corticosteroid therapy demonstrates rapid clearing of the parenchymal abnormalities within a few weeks, with a subsequent recurrence showing an identical pattern months later.
Key takeaways
Pulmonary graft-versus-host disease is a well-recognized non-infectious complication after allogeneic hematopoietic stem cell transplantation. It often presents with non-specific ground-glass opacities or organizing pneumonia patterns that are highly responsive to corticosteroids, though a thorough investigation with bronchoalveolar lavage is usually necessary to exclude opportunistic infections such as cytomegalovirus or Pneumocystis jirovecii.
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