CTICasesDiffuse Large B-Cell Lymphoma mimicking IgG4-Related Disease
Imaging findings
CT chest and abdomen shows extensive, lobulated, infiltrative pleural and extrapleural soft tissue masses encasing the mediastinum, associated with focal infiltrative soft tissue masses in the pancreas, porta hepatis, and paraspinal regions.
Key takeaways
Diffuse large B-cell lymphoma (DLBCL) can present with atypical, highly infiltrative, extra-nodal soft tissue masses in the thorax and abdomen. This pattern can closely mimic IgG4-related disease or retroperitoneal fibrosis, and core biopsy is essential to differentiate between benign fibroinflammatory disease and lymphoma.
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