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Subcutaneous silicone injection

Imaging findings

Chest radiographs and CT show diffuse, amorphous subcutaneous soft tissue thickening and extensive, dense calcification/foreign material within the chest wall and breast tissues, along with calcified axillary lymphadenopathy, in a transgender female patient with a history of free silicone cosmetic injections.

Key takeaways

Injection of free liquid silicone for cosmetic purposes can lead to chronic foreign body reaction, migration of silicone, tissue necrosis, and dense subcutaneous calcification over time, mimicking an active soft tissue infection on imaging.

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