CTICasesProfound Paraseptal Emphysema in a Non-Smoker
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Imaging findings
Chest CT in a young female who is a never-smoker with no occupational exposures demonstrates diffuse, profound paraseptal emphysema tracing along the pulmonary fissures and subpleural regions of the lungs, in the absence of centrilobular emphysema, airway disease, or parenchymal fibrosis.
Key takeaways
Severe, isolated paraseptal emphysema in young, non-smoking patients is a rare, poorly understood entity. It may represent an underlying, subclinical connective tissue disorder or genetic collagen abnormality, and places patients at high risk for spontaneous pneumothorax due to the rupture of large subpleural blebs.
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