CTICasesDiffuse Pulmonary Adenocarcinoma Mimicking Interstitial Lung Disease
Imaging findings
Frontal chest radiograph and chest CT demonstrate diffuse, poorly defined centrilobular and peribronchovascular nodules with ground-glass halos and a mass-like consolidation in the right middle lobe. Following targeted therapy with an EGFR inhibitor, a follow-up CT shows substantial regression of the nodules, leaving behind bizarre, diffuse reticular scars, microcystic lung changes, and architectural distortion.
Key takeaways
Primary lung adenocarcinoma, particularly the mucinous subtype, can present with diffuse, ill-defined ground-glass nodules mimicking infectious, inflammatory, or lymphoproliferative processes. When treated successfully with EGFR inhibitors, the resulting response can leave atypical, fibrotic-like scars and microcystic changes that resemble end-stage interstitial lung disease.
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