CTICasesGranulomatous-Lymphocytic Interstitial Lung Disease (GLILD) in Common Variable Immunodeficiency (CVID)
▶ Watch on YouTube — age-restricted, cannot embed here
Imaging findings
Chest x-ray shows extensive, bilateral, and diffuse lung disease, primarily in the lower lung zones, characterized by subsegmental, ill-defined opacities. CT demonstrates significant airway disease, including thickened bronchial walls and areas where small airways and bronchioles may contain material in their lumens. Expiratory imaging sequences reveal prominent air trapping, particularly in the upper lungs. The large opacities are speculated to be combinations of granulomatous findings and lymphocytes.
Key takeaways
Patients with Common Variable Immunodeficiency (CVID) are prone to developing Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD). Imaging features of GLILD include a combination of airway disease (follicular bronchiolitis, bronchial wall thickening, mucostasis), ground-glass or consolidated opacities, and air trapping. The opacities can be due to lymphoid interstitial pneumonia (LIP) or granulomatous inflammation. Expiratory CT is important to detect air trapping secondary to bronchiolar obstruction.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Miliary Tuberculosis with Ghon ComplexInfection
- Contained Left Ventricular Rupture with Large ThrombusVascular
- Pulmonary Arterial Hypertension (Group 1) in Elderly PatientVascular
- Coiled Ascending Aortic Pseudoaneurysm Post-Dissection RepairVascular
- Mitral-Aortic Intervalvular Fibrosa Pseudoaneurysm Post-Mitral Valve ReplacementVascular
- Infected Ascending Aortic Graft (Culture-Negative)Infection
- Missed Type A Aortic Dissection with Giant Ascending Aortic AneurysmVascular
- Cystic Lung Disease secondary to Crack Cocaine Use (Crack Lung)Exposure
See all cases from May 15, 2015 →
Related ILD cases
- Progressive Interstitial Lung Fibrosis with Dendriform Ossifications
- Asymmetric Interstitial Lung Fibrosis in Systemic Sclerosis
- Lymphocytic Interstitial Pneumonia (LIP) in Sjögren Syndrome
- Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD) with Obstructive Small Airways Disease in CVID
- Waxing and Waning Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD)
- Eosinophilic Pneumonia and Asthma