CTICasesAirway Aspergillus Colonization in GVHD
Imaging findings
CT chest in a post-stem cell transplant patient with graft-versus-host disease (GVHD) shows multiple cavitating nodules in a peribronchial distribution, associated with mosaic perfusion and air trapping on expiratory imaging.
Key takeaways
In severely immunocompromised patients (especially post-transplant on high-dose steroids for GVHD), Aspergillus can colonize the airways or cause invasive tracheobronchial aspergillosis. This typically presents with peribronchial nodules, bronchial thickening, and air trapping from bronchiolar involvement.
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