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Post-Transplant Lymphoproliferative Disorder

Imaging findings

SPECT-CT and diagnostic chest CT in a lung transplant recipient demonstrate multiple new, bilateral, progressive pulmonary nodules and masses, with the largest in the left lower lobe, along with mediastinal and hilar lymphadenopathy. Biopsy confirmed a diffuse large B-cell lymphoma (DLBCL) variant of post-transplant lymphoproliferative disorder (PTLD).

Key takeaways

Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of lymphoid proliferations occurring in immunosuppressed transplant recipients, often driven by Epstein-Barr virus (EBV). The pulmonary presentation typically consists of multiple nodular lesions, which must be distinguished from fungal or bacterial opportunistic infections.

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