CTICasesVaccine-Associated Myopericarditis
Imaging findings
Cardiac MRI of a 19-year-old male presenting with chest pain shortly after receiving an mRNA COVID-19 vaccine demonstrates global left ventricular hypokinesia with a severely reduced ejection fraction of approximately 30%. T2 mapping and late gadolinium enhancement (LGE) imaging reveal myocardial edema and patchy, mid-myocardial late enhancement compatible with myopericarditis.
Key takeaways
Myopericarditis is a rare, documented adverse event following vaccination, particularly with mRNA COVID-19 vaccines in young male recipients, typically manifesting within a few days of the second dose. Cardiac MRI is the gold standard for diagnosis, characterizing the classic triad of myocardial dysfunction, edema, and mid-myocardial or subepicardial late gadolinium enhancement, which generally portends a favorable prognosis with standard medical management.
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