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Disseminated Cryptococcus neoformans infection

Imaging findings

Chest CT in a 41-year-old HIV-positive male shows unilateral pleural effusion and extensive, nodular pleural thickening and mediastinal lymphadenopathy. Pleural fluid culture and CSF grew Cryptococcus neoformans.

Key takeaways

Disseminated Cryptococcus neoformans infection in HIV/AIDS patients can present with atypical pulmonary manifestations, such as extensive nodular pleural thickening and effusion, mimicking pleural mesothelioma or metastatic disease. It resolves following antifungal treatment.

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