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Brown Tumors in Primary Hyperparathyroidism

Imaging findings

CT chest and skeletal survey show multiple expansile, lytic bone lesions in the humeral heads, scapula, and ribs, associated with a pathological humerus fracture and medullary nephrocalcinosis in the kidneys.

Key takeaways

Brown tumors are non-neoplastic, expansile lytic bone lesions caused by osteoclast hyperfunction in severe hyperparathyroidism (typically primary, from an adenoma). They closely mimic multiple myeloma or osteolytic metastases, but lack extraosseous soft-tissue components and are accompanied by nephrocalcinosis.

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