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Pulmonary parenchymal amyloidosis

Imaging findings

Chest CT demonstrates diffuse, relatively smooth thickening of the interlobular septa throughout the lungs with some consolidation at the right lung base, simulating pulmonary edema, in a patient with a parotid gland biopsy positive for amyloid.

Key takeaways

Pulmonary parenchymal amyloidosis can manifest as diffuse interlobular septal thickening, mimicking interstitial pulmonary edema or lymphangitic carcinomatosis. It is a rare manifestation of systemic amyloidosis, and its presence can be independent of severe cardiac amyloid involvement.

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