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Evolution of rheumatoid arthritis-associated ILD (RA-ILD)

Imaging findings

Serial CT scans over 9 years show progression of RA-ILD from a mild, peripheral, lower-lobe predominant ground-glass and reticular pattern (NSIP-like) to advanced subpleural honeycombing and traction bronchiectasis (UIP-like).

Key takeaways

RA-ILD can histologically and radiographically evolve over time. An initial NSIP-like pattern can progress to a classic UIP-like pattern with honeycombing, reflecting progressive fibrotic remodeling.

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