CTICasesGranulomatous-Lymphocytic Interstitial Lung Disease in CVID
Imaging findings
CT chest in a patient with CVID shows multiple, diffuse pulmonary nodules, bronchovascular thickening, splenomegaly, and progressive, lower-zone-predominant fibrotic changes with traction bronchiectasis.
Key takeaways
Granulomatous-lymphocytic interstitial lung disease (GLILD) is a severe, non-infectious manifestation of common variable immunodeficiency (CVID). It is characterized by mixed granulomatous and lymphoproliferative pulmonary nodules, which can slowly progress to irreversible pulmonary fibrosis if untreated.
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