CTICasesMDA5 Dermatomyositis associated RPILD
Imaging findings
Serial CT chest scans show rapid progression of peribronchial/perilobular consolidation and ground-glass opacities in the lower lobes, developing traction bronchiectasis and lung volume loss over 6 weeks. The patient was MDA5 antibody positive and died from respiratory failure.
Key takeaways
Anti-MDA5 antibody-associated dermatomyositis is characterized by clinically amyopathic disease and rapidly progressive interstitial lung disease (RPILD). Early CT findings typically mimic organizing pneumonia before rapidly progressing to end-stage fibrosis.
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