CTICasesForeign Body Granuloma from BioSentry Biopsy Tract Sealant
Imaging findings
Pre-operative CT of a patient with a biopsy-proven adenocarcinoma of the left upper lobe demonstrates a linear, worm-like, soft tissue density tract extending from the pleura to the nodule that was not present on the pre-biopsy CT. Histopathological analysis of the wedge resection specimen shows foreign body granulomatous reaction along the biopsy tract, corresponding to remnants of a BioSentry hydrogel tract-sealing plug.
Key takeaways
Tract-sealing systems like the BioSentry hydrogel plug are designed to be deployed along a lung biopsy tract to reduce the risk of post-procedural pneumothorax. Although advertised as fully resorbable, these synthetic polymers can persist and incite a chronic foreign body granulomatous reaction, which can mimic tumor seeding or a parasitic infection on follow-up imaging.
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