CTICasesIdiopathic Airway-Centered Fibrosis
Imaging findings
CT chest shows diffuse peribronchovascular thickening, reticulation, and patchy ground-glass opacities in an airway-centered distribution, without honeycombing. Surgical lung biopsy confirmed chronic airway-centered fibrosis and follicular bronchiolitis, in a patient with negative autoimmune panels.
Key takeaways
Chronic airway-centered fibrosis is an interstitial lung disease pattern characterized by fibrosis and inflammation surrounding the bronchioles. It is strongly associated with connective tissue diseases, common variable immunodeficiency (CVID), or environmental exposures, but idiopathic cases occur and require long-term clinical monitoring.
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