CTICasesDiffuse Panbronchiolitis
Imaging findings
CT chest shows diffuse, symmetric centrilobular nodules and branching tree-in-bud opacities, with bronchiectasis and peribronchial thickening in the lower lobes. Pathological biopsy confirmed diffuse panbronchiolitis (DPB), showing accumulation of foamy histiocytes in the respiratory bronchioles.
Key takeaways
Diffuse panbronchiolitis (DPB) is a chronic inflammatory airway disease classically seen in East Asian populations. It is characterized by progressive bronchiolitis and bronchiectasis, and histopathology demonstrates interstitial foamy histiocytes in the respiratory bronchiolar walls. Early diagnosis is important as it responds well to low-dose macrolide therapy.
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