CTICasesFocal Pulmonary Fibrosis
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Imaging findings
CT angiography demonstrates a persistent ground-glass lesion in the middle lobe with cystic components and bubble-like lucencies, along with a separate nodular ground-glass lesion in the lower lobe. Wedge resection of the middle lobe reveals focal chronic lymphocytic infiltration with fibrosis and no evidence of adenocarcinoma.
Key takeaways
Focal pulmonary fibrosis and localized chronic lymphocytic inflammation can present on chest CT as persistent ground-glass lesions containing cystic or bubble-like lucencies, highly mimicking low-grade adenocarcinoma (such as minimally invasive adenocarcinoma or adenocarcinoma in situ). Histological examination is often required for definitive diagnosis when these lesions persist or grow.
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