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Recurrent Hypersensitivity Pneumonitis (Hot Tub Lung) Post-Lung Transplant

Imaging findings

High-resolution chest CT in a bilateral lung transplant recipient shows progressive ground-glass opacities, centrilobular nodules, and expiratory air trapping. The patient's native lungs had been explanted for chronic hypersensitivity pneumonitis secondary to Mycobacterium avium complex (MAC) from hot tub exposure. Bronchoscopy of the transplanted lung demonstrated non-necrotizing granulomas and organizing pneumonia, consistent with recurrent hypersensitivity pneumonitis following use of a new "swim spa."

Key takeaways

Hypersensitivity pneumonitis (such as hot tub lung) can recur in the allograft of lung transplant recipients upon re-exposure to the environmental antigen, even in the setting of post-transplant immunosuppressive therapy.

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