CTICasesMedullary Thyroid Cancer Calcitonin Amyloidosis
Imaging findings
Chest CT in a patient with a history of medullary thyroid cancer shows stable cystic lung disease over a decade, with perivascular thin-walled cysts. There is also a large bronchial artery aneurysm and severe chest wall narrowing (straight back syndrome).
Key takeaways
Medullary thyroid cancer produces high levels of calcitonin, which can deposit systemically as amyloid. In the lungs, calcitonin-derived amyloid deposition can manifest as chronic, slowly progressive cystic lung disease.
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