CTICasesAdenocarcinoma in Smoking-Related Interstitial Fibrosis
Imaging findings
CT chest shows a small ground-glass nodule arising within a background of smoking-related interstitial fibrosis (SRIF) and emphysema. Follow-up CT one year later shows growth of the nodule with a new solid component, proven to be adenocarcinoma with a micropapillary component.
Key takeaways
Lung cancer screening is highly effective in patients with underlying pulmonary fibrosis, who have a significantly elevated risk of developing lung cancer. Cancers arising in fibrotic regions can be very difficult to detect early, and even small nodules can contain aggressive histopathological subtypes (like micropapillary adenocarcinoma).
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