CTICasesScleroderma-Rheumatoid Arthritis Overlap with UIP
Imaging findings
Hand radiographs show classic features of both rheumatoid arthritis (joint deformities) and systemic sclerosis (acro-osteolysis of distal phalanges and extensive soft tissue calcinosis). CT chest shows lower-lobe-predominant subpleural honeycombing and traction bronchiectasis (UIP pattern).
Key takeaways
Connective tissue disease overlap syndromes, such as systemic sclerosis (scleroderma) and rheumatoid arthritis overlap, can present with severe extra-thoracic and thoracic manifestations. Unlike idiopathic UIP, CTD-UIP often has a slightly better prognosis but requires careful immunosuppressive management.
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