CTICasesAnti-Jo-1 Anti-Synthetase Syndrome Interstitial Lung Disease
Imaging findings
CT chest shows rapidly progressive, bilateral, lower-lobe-predominant ground-glass opacities and consolidations. The patient was found to have a positive anti-Jo-1 antibody, representing a mixture of organizing pneumonia (OP) and cellular NSIP.
Key takeaways
Anti-synthetase syndrome is an autoimmune disease characterized by myositis, interstitial lung disease, arthritis, Raynaud's phenomenon, and 'mechanic's hands.' The anti-Jo-1 antibody is the most common autoantibody. Pulmonary involvement typically manifests as an OP/NSIP overlap pattern, showing a good response to steroids and mycophenolate.
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