CTICasesDiffuse Pulmonary Extramedullary Hematopoiesis in Myelofibrosis
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Imaging findings
Initial imaging showed diffusely gray lungs, with a small left pleural effusion and sparse septal lines, suggesting some associated edema. Subsequent CT performed later also demonstrated diffusely gray lungs, confirming extensive diffuse pulmonary abnormality. The patient had myelofibrosis, and a biopsy confirmed the diagnosis of diffuse pulmonary extramedullary hematopoiesis. Prosthetic valves were also noted from prior surgery.
Key takeaways
Diffuse pulmonary extramedullary hematopoiesis (EMH), a rare manifestation of myelofibrosis, can present as diffusely gray or ground-glass opacified lungs on CT due to the accumulation of hematopoietic cells. This appearance can mimic pulmonary edema or other diffuse lung diseases. In the context of myelofibrosis, EMH should be considered in the differential diagnosis, though biopsy is typically required for definitive confirmation.
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