CTICasesPleural Extramedullary Hematopoiesis in Myelofibrosis
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Imaging findings
CT demonstrates a large left pleural effusion and associated soft-tissue pleural masses, along with diffuse osteosclerosis of the visualized skeleton. There is also a large, adjacent subscapular soft-tissue hematoma.
Key takeaways
Pleural extramedullary hematopoiesis is an uncommon manifestation of myelofibrosis that can present as recurrent, hemorrhagic pleural effusions or soft-tissue pleural masses. Cytological evaluation of the pleural fluid or pleural biopsy confirms the diagnosis by demonstrating a mixture of hematopoietic cell lines, including erythroid, myeloid, and megakaryocytic precursors.
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