CTICasesInvasive Squamous Cell Carcinoma Mimicking Lymphoma
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Imaging findings
A 33-year-old woman presented with bulky lymphadenopathy in multiple mediastinal stations (including internal mammary nodes), airway narrowing, pleural effusion, and lymphatic distribution of abnormalities (septal lines, peribronchovascular consolidation). Biopsy of a node revealed invasive differentiated squamous cell carcinoma, with no known primary.
Key takeaways
Squamous cell carcinoma, even without an identifiable primary, can present with extensive mediastinal lymphadenopathy and lymphatic carcinomatosis, mimicking the appearance of lymphoma. This case highlights how different malignancies can present with similar imaging features, emphasizing the need for biopsy for definitive diagnosis.
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