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Lymphoma Presenting with Pericardial Effusion

Lymphoma Presenting with Pericardial Effusion▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

A patient presenting with chest pain was initially thought to have cardiomegaly, but imaging revealed a significant pericardial fluid accumulation. Further evaluation showed widespread lymph node disease (paraaortic, paratracheal) and an infiltrative process within the mediastinum, particularly near the atrium. Biopsy confirmed a B-cell lymphoma.

Key takeaways

Lymphoma can present atypically with significant pericardial effusion causing chest pain, in addition to more characteristic findings like mediastinal lymphadenopathy and infiltrative soft tissue masses. Pericardial involvement can be a primary manifestation leading to initial presentation.

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