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Posterior Mediastinal Liposarcoma with Pleural Spillage

Imaging findings

CT demonstrates a large, well-rounded 15-cm fat-containing mass in the posterior mediastinum, which was surgically resected and diagnosed as a myxoid liposarcoma. Postoperative CT three months later shows rapid, extensive recurrence throughout the left pleural space due to intraoperative tumor spillage.

Key takeaways

Primary mediastinal liposarcomas are rare mesenchymal tumors. Surgical resection is the primary treatment, but intraoperative rupture or spillage can lead to rapid, extensive pleural dissemination that mimics primary pleural malignancy.

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