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Reversible Airway Contraction in Immunodeficiency

Imaging findings

CT in an immunodeficient patient with pre-existing bronchiectasis shows severe, diffuse contraction and narrowing of the bronchitic airways during an acute airway infection. Follow-up CT six days after initiating antibiotic therapy shows that the airways have popped back open to their baseline caliber.

Key takeaways

Bronchitic airways in patients with immunodeficiency can show dramatic, reversible contraction and narrowing in the setting of acute infection, likely representing bronchospasm and dynamic inflammatory airway collapse that resolves with therapy.

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